m

ke tit e n ec SUMMARYmyelination has been shown to correlate well with the expression of chaperone proteins to facilitate protein have beenprotein 1 (PLP1) gene has been identified as a causative gene for PMD. PLP1 is a transmembrane protein that is shown to activate apoptotic pathway of UPR to eliminate damaged OLs.clinical severity of PMD (Seitelberger, 1995). The proteolipid folding, excessive levels of unfolded proteinsINTRODUCTION Analysis of differentiated cells from disease-specific, hu-man induced pluripotent stem cells (iPSCs) enables the construction of pathological models using the patients’ own cells. Such analyses are particularly useful for the study of neurodegenerative disorders because it is difficul