RESEARCH ARTICLE f

cu ea eu the AR tients, adoptive T-cell therapy has been improved by intro- Cancer stem cells (CSCs) enable the tumor to grow Deng et al. BMC Immunology (2015) 16:1 DOI 10.1186/s12865-014-0064-xtherapy that targets cancer stem cell antigen, epithelial cell adhesion molecule (EpCAM). Studies have shown Medical College and Chinese Academy of Medical Sciences, Beijing 100021, Chinaducing antigen receptors into circulating lymphocytes. To do this, genes encoding T-cell receptors isolated from high avidity, tumor-specific T cells or chimeric antigen recep-tors (CAR) containing an antibody-based external receptor structure and intracellular T-cell signaling domains, such and metastasize, therefore, eradicating CSCs is expected to provide cancer patients long-term disease-free sur-vival. However, CSCs have also been demonstrated to be more resistant to chemotherapy and radiotherapy [6]. Currently, the research on immunotherapies targeting CSCs is limited. In this study, we developed a new adoptive immuno- * Correspondence