RESEARCH ARTICLE Revealing the Molecular Portrait of Triple Negative Breast Tumors in an Understudied Population through Omics Analysis of Formalin-Fixed and Paraffin-Embedded Tissues

Triple negative breast cancer (TNBC), defined by the lack of expression of the estrogen re-ceptor, progesterone receptor and human epidermal receptor 2, is an aggressive form of breast cancer that is more prevalent in certain populations, in particular in low- and middle-income regions. The detailed molecular features of TNBC in these regions remain unex-plored as samples are mostly accessible as formalin-fixed paraffin embedded (FFPE) ar-chived tissues, a challenging material for advanced genomic and transcriptomic studies. Using dedicated reagents and analysis pipelines, we performed whole exome sequencing and miRNA and mRNA profiling of 12 FFPE tumor tissues collected from pathological ar-chives in Mexico. Sequencing analyses of the tumor tissues and their blood pairs identifie