Central European Journal of Urology

and in combination with alfuzosin for the management of lower urinary tract symptoms. Cent European J Urol. 2015; 68: 51-56. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor, which inhibits the activity of both isoforms of COX (1 and 2). Also, flurbiprofen is one of the most potent non-steroidal anti-inflammatory agent (NSAIDs) in terms of prostaglandin inhibitory ac-tivity via reversible inhibition of COX, the enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prosta-glandin H2 (PGH2). COX exists as two isoforms, con-stitutive COX-1 and inducible COX-2. Prostaglandins (PGs) formed by COX-1 are primarily involved in the regulation of homeostatic functions in physiological processes, whereas PGs formed by COX-2 primarily mediate pain, inflammation, and cancer pathophysi