RESEARCH ARTICLE MicroRNA-302b suppresse

an co effectively diagnosing HCC at its early stage, only about 10 to 20 % of patients with hepatocellular carcinoma are key regulators of various fundamental biological pro-cesses, such as development, differentiation, apoptosis, Wang et al. BMC Cancer 2013, 13:448 http://www.biomedcentral.com/1471-2407/13/448genetic and genomic alterations. Fourth, several miRNAsJiaotong University Health Science Center, Xi’an, Shaanxi, China Full list of author information is available at the end of the articlecurrently eligible for surgical intervention [2-6]. There-fore, elucidating the molecular mechanisms involved in HCC is essential for developing cancer prevention and cell proliferation, in which common pathways are shared with cancer [8-11]. Second, bioinformation ana-lyses estimate that miRNAs may regulate as much as 30 % of the human protein coding genes, including onco-genes and tumor suppressors, suggesting that these small RNAs may act to coordinate the interplay between complex signal transduction pathways [12]. Third, in-creasing evidence shows that the expression of miRNAs is remarkably deregulated in cancer due to multiple epi