Polymorphic variation in the apolipoprotein E (apoE) gene is the major genetic susceptibility factor for late-onset Alzheimer’s disease (AD) and likely contributes to neuropathology through various pathways. It is also recognized that apoE undergoes proteolytic cleavage in the brain and the resultant apoE fragments likely have a variety of bioactive properties that regulate neuronal signaling and may promote neurodegeneration. ApoE fragmentation in the human brain has been intensively studied using different immunochemical methods, but has never been analyzed in a quantitative manner to establish preferably accumulated fragments. Here we report quantification using multiple reaction monitoring mass spectrometry (MRM MS) with 15N-labeled ful...
Polymorphic alleles in the apolipoprotein E (APOE) gene are the main genetic determinants of late-on...
Polymorphic alleles in the apolipoprotein E (APOE) gene are the main genetic determinants of late-on...
Background: Aggregation of amyloid β into plaques in the brain is one of the earliest pathological e...
Polymorphic variation in the apolipoprotein E (apoE) gene is the major genetic susceptibility factor...
Apolipoprotein E isoforms (apoE2, apoE3, and apoE4) affect the likelihood of developing Alzheimer’s ...
Although the risk factor for harboring the apolipoprotein E4 (apoE4) allele in late-onset Alzheimer’...
Background: The human APOE gene, which codes for apolipoprotein E (apoE), has three major polymorphi...
AbstractA targeted mass spectrometric assay was developed for identification and quantification of a...
International audienceIdentification of endogenous pathological amyloid β peptides (Aβ) forms in the...
Apolipoprotein E (apoE) is a constitute of several lipoprotein particles with an important role in l...
Background Aggregation of amyloid beta into plaques in the brain is one of the earliest pathological...
<p>a) Using poly-clonal antibody, the distribution of ApoE fragments is clearly different between he...
Polymorphic alleles in the apolipoprotein E (APOE) gene are the main genetic determinants of late-on...
Apolipoprotein-E (apoE) plays important roles in neurobiology and the apoE4 isoform increases risk f...
Polymorphic alleles in the apolipoprotein E (APOE) gene are the main genetic determinants of late-on...
Polymorphic alleles in the apolipoprotein E (APOE) gene are the main genetic determinants of late-on...
Polymorphic alleles in the apolipoprotein E (APOE) gene are the main genetic determinants of late-on...
Background: Aggregation of amyloid β into plaques in the brain is one of the earliest pathological e...
Polymorphic variation in the apolipoprotein E (apoE) gene is the major genetic susceptibility factor...
Apolipoprotein E isoforms (apoE2, apoE3, and apoE4) affect the likelihood of developing Alzheimer’s ...
Although the risk factor for harboring the apolipoprotein E4 (apoE4) allele in late-onset Alzheimer’...
Background: The human APOE gene, which codes for apolipoprotein E (apoE), has three major polymorphi...
AbstractA targeted mass spectrometric assay was developed for identification and quantification of a...
International audienceIdentification of endogenous pathological amyloid β peptides (Aβ) forms in the...
Apolipoprotein E (apoE) is a constitute of several lipoprotein particles with an important role in l...
Background Aggregation of amyloid beta into plaques in the brain is one of the earliest pathological...
<p>a) Using poly-clonal antibody, the distribution of ApoE fragments is clearly different between he...
Polymorphic alleles in the apolipoprotein E (APOE) gene are the main genetic determinants of late-on...
Apolipoprotein-E (apoE) plays important roles in neurobiology and the apoE4 isoform increases risk f...
Polymorphic alleles in the apolipoprotein E (APOE) gene are the main genetic determinants of late-on...
Polymorphic alleles in the apolipoprotein E (APOE) gene are the main genetic determinants of late-on...
Polymorphic alleles in the apolipoprotein E (APOE) gene are the main genetic determinants of late-on...
Background: Aggregation of amyloid β into plaques in the brain is one of the earliest pathological e...