RESPONSE TO COMMENT ON DUTIA ET AL. Limited Recovery of b-Cell Function After Gastric Bypass Despite Clinical Diabetes Remission. Diabetes 2014;63:

We thank Dr. Pontiroli, and agree with his commentary (1). Dr. Pontiroli provides an interesting observation regarding change in b-cell function following weight loss by gastric banding in subjects with type 2 diabetes. His data show minimal improvement in insulin release, as assessed by the Dinsulin/Dglucose during an oral glucose tolerance test (OGTT), but a significant improvement in insulin sen-sitivity by homeostasis model assessment, 18 months after gastric banding (1,2). In our study (3), we observed a signif-icant improvement in both b-cell glucose sensitivity (slope of the insulin response to a change in plasma glucose levels) during an oral glucose challenge, and insulin sensitivity by homeostasis model assessment, after 10 % and 30 % weight loss by Roux-en-Y gastric bypass (RYGBP). The improve-ment in insulin secretion after RYGBP and the lack o