The circadian clock orchestrates temporal patterns of physiology and behavior relative to the environmental light:dark cycle by generating and organizing transcriptional and biochemical rhythms in cells and tissues throughout the body. Circadian clock genes have been shown to regulate the physiology and function of the gastrointestinal tract. Disruption of the intestinal epithelial barrier enables the translocation of proinflammatory bacterial products, such as endotoxin, across the intestinal wall and into systemic circulation; a process that has been linked to pathologic inflammatory states associated with metabolic, hepatic, cardiovascular and neurodegenerative diseases – many of which are commonly reported in shift workers. Here we repo...
BackgroundIt is well-established that several features of modern lifestyles, such as shift work, jet...
<p>Young adult (7–9 week) male <i>Clock<sup>Δ19/Δ19</sup></i> mutant mice (C, n = 10) exhibited incr...
<p>Young adult (7–9 week) male C57BL/6J mice underwent three months of weekly 12 hour phase shifts o...
The circadian clock orchestrates temporal patterns of physiology and behavior relative to the enviro...
Disrupted circadian rhythms and alterations of the gut microbiome composition were proposed to affec...
<p>(<b>A</b>) Urinary sucralose excretion was measured as an index of colon permeability. Alcohol-fe...
Endogenous circadian clocks regulate 24-h rhythms of physiology and behavior. Circadian rhythm disru...
BACKGROUND & AIMS: The circadian clock drives daily rhythms in behavior and physiology. A recent stu...
Background & Aims: The circadian clock drives daily rhythms in behavior and physiology. A recent...
Diurnal (i.e., 24-hour) oscillations of the gut microbiome have been described in various species in...
The circadian clock drives daily rhythms in behavior and physiology. A recent study suggests that in...
BackgroundIt is well-established that several features of modern lifestyles, such as shift work, jet...
BackgroundIt is well-established that several features of modern lifestyles, such as shift work, jet...
We evaluated the mechanistic link between circadian rhythms and gut barrier permeability. Mice were ...
Circadian rhythms govern glucose homeostasis, and their dysregulation leads to complex metabolic dis...
BackgroundIt is well-established that several features of modern lifestyles, such as shift work, jet...
<p>Young adult (7–9 week) male <i>Clock<sup>Δ19/Δ19</sup></i> mutant mice (C, n = 10) exhibited incr...
<p>Young adult (7–9 week) male C57BL/6J mice underwent three months of weekly 12 hour phase shifts o...
The circadian clock orchestrates temporal patterns of physiology and behavior relative to the enviro...
Disrupted circadian rhythms and alterations of the gut microbiome composition were proposed to affec...
<p>(<b>A</b>) Urinary sucralose excretion was measured as an index of colon permeability. Alcohol-fe...
Endogenous circadian clocks regulate 24-h rhythms of physiology and behavior. Circadian rhythm disru...
BACKGROUND & AIMS: The circadian clock drives daily rhythms in behavior and physiology. A recent stu...
Background & Aims: The circadian clock drives daily rhythms in behavior and physiology. A recent...
Diurnal (i.e., 24-hour) oscillations of the gut microbiome have been described in various species in...
The circadian clock drives daily rhythms in behavior and physiology. A recent study suggests that in...
BackgroundIt is well-established that several features of modern lifestyles, such as shift work, jet...
BackgroundIt is well-established that several features of modern lifestyles, such as shift work, jet...
We evaluated the mechanistic link between circadian rhythms and gut barrier permeability. Mice were ...
Circadian rhythms govern glucose homeostasis, and their dysregulation leads to complex metabolic dis...
BackgroundIt is well-established that several features of modern lifestyles, such as shift work, jet...
<p>Young adult (7–9 week) male <i>Clock<sup>Δ19/Δ19</sup></i> mutant mice (C, n = 10) exhibited incr...
<p>Young adult (7–9 week) male C57BL/6J mice underwent three months of weekly 12 hour phase shifts o...