Research Article Astroglia-Microglia Cross Talk during Neurodegeneration in the Rat Hippocampus

  • Montserrat Batlle
  • Lorenzo Ferri
  • Carmen Andrade
  • Francisco-javier Ortega
  • Jose M. Vidal-taboada
  • Marco Pugliese
  • Nicole Mahy
  • Manuel J. Rodríguez
Publication date
August 2016

Abstract

Copyright © 2015 Montserrat Batlle et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Brain injury triggers a progressive inflammatory response supported by a dynamic astroglia-microglia interplay.We investigated the progressive chronic features of the astroglia-microglia cross talk in the perspective of neuronal effects in a ratmodel of hippocampal excitotoxic injury. N-Methyl-D-aspartate (NMDA) injection triggered a process characterized within 38 days by atrophy, neuronal loss, and fast astroglia-mediated S100B increase. Microglia reaction varied with the lesion progres...

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