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cients, although re-tion between MVPA sedentary time was cle under the CC BY rg/licenses/by/4.0/). Physical inactivity is a well-established risk factor for non-communicable diseases and premature mortality [1]. It influences cardiovascular risk factors, such as blood pressure, lipid profile and adiposity, and consequently, increases the risk of coronary heart ests that the time k factor for non-communicable diseases, independent of physical activity [4,5]. Non-communicable diseases, particularly cardiovascular dis-eases are the main causes of death in high- [6] and middle-income countries [7]. The prevalence of cardiovascular risk factors such as diabetes, hypertension and obesity has increased worldwide, and these risk factors are associated with unfavorable changes in life-style behaviors such as an unhealthy diet and low levels of physical activity [6,7]. Prevention of adult cardiovascular diseases implies detection and intervention in early life. Atherosclerosis is a chroni