NEWS CELL CyCLE NEWS & viEWS

Budding yeast is a preeminent model organ-ism in studies of cellular aging pathways that are conserved in eukaryotes, including humans. There are two primary ways to query the lifespan of this organism.1 if one asks how many times a cell can divide, the answer will be its replicative lifespan (RLS). if, on the other hand, one asks how long a cell can stay alive without dividing, the answer will be its chrono-logical lifespan (CLS). Budding yeast is a facultative aerobe with exceptional genetic tractability. Hence, many environmental and genetic factors are known to affect replicative and chronological lifespan. Since the context of the RLS and CLS assays i