Mechanism and Therapies

Copyright © 2014 Zhengyuan Xia et al.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Ischemia/reperfusion injury (IRI) and organ failure, espe-cially IRI-induced remote and multiple organ failure, con-tribute significantly to postoperativemortality andmorbidity, and reperfusion induced oxidative stress plays a critical role in this pathology. Postoperative mortality risk increases in aged patients and in patients with concomitant diseases like diabetes which itself is associated with increased oxidative stress. Given that people now live longer and are often with concomitant diseases, IRI in these population is more severe and prevention or treatment of IRI will be an increasing important area of intention. Ischemic heart disease is a major complication of dia-betes [1, 2]. Although expeditious percutaneous coronar