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Continuous infusion of levodopa or apomorphine provide constant dopaminergic stimula-tions are good alternatives to deep brain stimulation to control motor fluctuations in patients with advanced Parkinson’s disease (PD). Apomorphine provides motor benefit similar to do-pamine, but its long-term use is limited by compliance, mostly injection site skin reactions. Administration of levodopa/carbidopa by continuous duodenal infusion allows replacement of all oral medications and permits achievement of a satisfactory therapeutic response par-alleled by a reduction in motor complication severity. However, this procedure is more in-vasive than apomorphine as it requires a percutaneous endoscopic gastrostomy Clinical ex-perience with infusions shows that continuous dopaminergic stimulation of dopaminergic medications reduces dyskinesia and widens the therapeutic window in advanced PD