Add to ORKGCommon adverse symptoms of cancer and chemotherapy are a major health burden; chief among these is pain, with opioids including transdermal fentanyl the mainstay of treatment. Innate immune activation has been implicated generally in pain, opioid analgesia, cognitive dysfunction, and sickness type symptoms reported by cancer patients. We aimed to deter-mine if genetic polymorphisms in neuroimmune activation pathways alter the serum fenta-nyl concentration-response relationships for pain control, cognitive dysfunction, and other adverse symptoms, in cancer pain patients. Cancer pain patients (468) receiving transder-mal fentanyl were genotyped for 31 single nucleotide polymorphisms in 19 genes: CASP1
The number of cancer patients in the world is increasing mainly because of ageing populations. In de...
Background Human genetic research has implicated functional variants of more than one hundred genes ...
<p><sup>a</sup>Odds Ratio controlling for all other regressors.</p><p><sup>b</sup>Homozygous wildtyp...
Common adverse symptoms of cancer and chemotherapy are a major health burden; chief among these is p...
<div><p>Common adverse symptoms of cancer and chemotherapy are a major health burden; chief among th...
Common adverse symptoms of cancer and chemotherapy are a major health burden; chief among these is p...
Purpose: Patients treated with opioid drugs for cancer pain experience different relief responses, r...
Pain, fatigue, sleep disturbance, and depression are common and frequently co-occurring symptoms in ...
none14siBackground: Current understanding of genetic factors associated with pain severity, and impr...
Pain, fatigue, sleep disturbance, and depression are common and frequently co-occurring symptoms in ...
Abstract Aim Cancer pain impairs not only physical functions but also social functions and roles. Co...
PURPOSE: This paper summarizes current knowledge of pain-related and analgesic-related pathways as w...
Background: Human genetic research has implicated functional variants of more than one hundred genes...
Objectives: Proinflammatory cytokines released during inflammation can cause hyperexcitability in pa...
Item does not contain fulltextAIM: To assess association between genetic variants and opioid require...
The number of cancer patients in the world is increasing mainly because of ageing populations. In de...
Background Human genetic research has implicated functional variants of more than one hundred genes ...
<p><sup>a</sup>Odds Ratio controlling for all other regressors.</p><p><sup>b</sup>Homozygous wildtyp...
Common adverse symptoms of cancer and chemotherapy are a major health burden; chief among these is p...
<div><p>Common adverse symptoms of cancer and chemotherapy are a major health burden; chief among th...
Common adverse symptoms of cancer and chemotherapy are a major health burden; chief among these is p...
Purpose: Patients treated with opioid drugs for cancer pain experience different relief responses, r...
Pain, fatigue, sleep disturbance, and depression are common and frequently co-occurring symptoms in ...
none14siBackground: Current understanding of genetic factors associated with pain severity, and impr...
Pain, fatigue, sleep disturbance, and depression are common and frequently co-occurring symptoms in ...
Abstract Aim Cancer pain impairs not only physical functions but also social functions and roles. Co...
PURPOSE: This paper summarizes current knowledge of pain-related and analgesic-related pathways as w...
Background: Human genetic research has implicated functional variants of more than one hundred genes...
Objectives: Proinflammatory cytokines released during inflammation can cause hyperexcitability in pa...
Item does not contain fulltextAIM: To assess association between genetic variants and opioid require...
The number of cancer patients in the world is increasing mainly because of ageing populations. In de...
Background Human genetic research has implicated functional variants of more than one hundred genes ...
<p><sup>a</sup>Odds Ratio controlling for all other regressors.</p><p><sup>b</sup>Homozygous wildtyp...