Pearls Toll-Like Receptors Promote Mutually Beneficial Commensal-Host Interactions

Toll-like receptors (TLRs) are evolutionarily conserved trans-membrane receptors that detect micro-organisms through the recognition of conserved molecular motifs. With each TLR able to recognize a discrete set of microbial ligands, TLRs represent an important mechanism by which the host detects a variety of microorganisms. Triggering of TLRs by pathogens is classically understood to result in an inflammatory immune response that supports the subsequent clearance of the offending microbe. However, animals are stably colonized by a consortium of symbiotic microbes (the microbiota) that possess many of the same structural motifs as pathogens, which raises the question of how the host is able to peacefully coexist with this community of organisms without suffering from chronic inflammatory disease. Paradoxical to its pro-inflammatory role during infection, recent studies have suggested that commensal bacterial recognition b