Add to ORKGCo-infection with HIV-1 and Kaposi’s sarcoma-associated herpesvirus (KSHV) is the cause of ag-gressive AIDS-related Kaposi’s sarcoma (AIDS-KS) characterized by abnormal angiogenesis. The impact of HIV-1 and KSHV interaction on the pathogenesis and extensive angiogenesis of AIDS-KS remains un-clear. Here, we explored the synergistic effect of HIV-1 Tat and KSHV oncogene Orf-K1 on angiogenesis. Our results showed that soluble Tat or ectopic expression of Tat enhanced K1-induced cell proliferation, micro-tubule formation and angiogenesis in chorioallantoic membrane and nude mice models. Mechanistic stud-ies revealed that Tat promoted K1-induced angiogen-esis by enhancing NF-B signaling. Mechanistically
The Tat protein of human immunodeficiency virus (HIV) type 1 is a transactivator of viral gene expre...
Kaposi sarcoma-associated herpesvirus (KSHV) is necessary but not sufficient to cause Kaposi sarcoma...
Kaposi's sarcoma (KS) is a vascular tumor frequently occurring in Human Immunodeficiency Virus- (HIV...
Kaposi’s sarcoma (KS)-associated herpesvirus (KSHV) is etiologically associated with KS, the most co...
Kaposi’s sarcoma (KS)-associated herpesvirus (KSHV) is etiologically associated with KS, the most co...
The Tat protein of HIV-1, a transactivator of viral gene expression, is released by acutely infected...
The Tat protein of HIV-1, a transactivator of viral gene expression, is released by acutely infected...
The Tat protein of HIV-1, a transactivator of viral gene expression, is released by acutely infected...
Extracellular human immunodeficiency virus type 1 (HIV-1) Tat protein promotes growth of spindle cel...
In the HAART era Kaposi’s sarcoma (KS) remains the second most frequent tumor in HIV-infected patie...
Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is etiologically associated with KS, the most co...
The Tat protein of human immunodeficiency virus type-1 (HIV-1) has been shown to be released during ...
The Tat protein of human immunodeficiency virus (HIV) type 1 is a transactivator of viral gene expre...
Kaposi sarcoma-associated herpesvirus (KSHV) is necessary but not sufficient to cause Kaposi sarcoma...
Kaposi's sarcoma (KS) is a vascular tumor frequently occurring in Human Immunodeficiency Virus- (HIV...
Kaposi’s sarcoma (KS)-associated herpesvirus (KSHV) is etiologically associated with KS, the most co...
Kaposi’s sarcoma (KS)-associated herpesvirus (KSHV) is etiologically associated with KS, the most co...
The Tat protein of HIV-1, a transactivator of viral gene expression, is released by acutely infected...
The Tat protein of HIV-1, a transactivator of viral gene expression, is released by acutely infected...
The Tat protein of HIV-1, a transactivator of viral gene expression, is released by acutely infected...
Extracellular human immunodeficiency virus type 1 (HIV-1) Tat protein promotes growth of spindle cel...
In the HAART era Kaposi’s sarcoma (KS) remains the second most frequent tumor in HIV-infected patie...
Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is etiologically associated with KS, the most co...
The Tat protein of human immunodeficiency virus type-1 (HIV-1) has been shown to be released during ...
The Tat protein of human immunodeficiency virus (HIV) type 1 is a transactivator of viral gene expre...
Kaposi sarcoma-associated herpesvirus (KSHV) is necessary but not sufficient to cause Kaposi sarcoma...
Kaposi's sarcoma (KS) is a vascular tumor frequently occurring in Human Immunodeficiency Virus- (HIV...