The p38 mitogen-activated protein (MAP) kinase signaling cassette has been implicated in stress and immunity in evolutionarily diverse species. In response to a wide variety of physical, chemical and biological stresses p38 kinases phosphorylate various substrates, transcription factors of the ATF family and other protein kinases, regulating cellular adaptation to stress. The Drosophila genome encodes three p38 kinases named p38a, p38b and p38c. In this study, we have analyzed the role of p38c in the Drosophila intestine. The p38c gene is expressed in the midgut and upregulated upon intestinal infection. We showed that p38c mutant flies are more resistant to infection with the lethal pathogen Pseudomonas entomophila but are more susceptible...
BackgroundFruit flies and mammals protect themselves against infection by mounting immune and metabo...
[[abstract]]Local infections can trigger immune responses in distant organs, and this interorgan imm...
[[abstract]]Local infections can trigger immune responses in distant organs, and this interorgan imm...
<div><p>The p38 mitogen-activated protein (MAP) kinase signaling cassette has been implicated in str...
Accumulating evidence suggests that the insect and mammalian innate immune response is mediated by h...
<p>(<b>A</b>) <i>p38c<sup>7B1</sup></i> and <i>Mekk1<sup>Ur36</sup></i> mutants accumulate lipids in...
The integrity of the intestinal epithelium is crucial for the barrier function of the gut. Replenish...
<p>(<b>A</b>) The induction of <i>Duox</i> upon <i>P. entomophila</i> infection is reduced in <i>p38...
SummaryMolecular mechanisms that concordantly regulate stress, life span, and aging remain incomplet...
NF-кB/Rel family proteins regulate genes that are critical for many cellular processes including apo...
Septic injury triggers a rapid and widespread response in Drosophila adults that involves the up-reg...
Cells commonly use multiprotein kinase cascades to signal information from the cell membrane to the ...
DUOX, a member of the NADPH oxidase family, acts as the first line of defense against enteric pathog...
<p>(<b>A</b>) Data from Flyatlas showed an enrichment of p38c in the midgut <a href="http://www.plos...
The target of rapamycin (TOR) complex 1 (TORC1) signaling pathway is a critical regulator of transla...
BackgroundFruit flies and mammals protect themselves against infection by mounting immune and metabo...
[[abstract]]Local infections can trigger immune responses in distant organs, and this interorgan imm...
[[abstract]]Local infections can trigger immune responses in distant organs, and this interorgan imm...
<div><p>The p38 mitogen-activated protein (MAP) kinase signaling cassette has been implicated in str...
Accumulating evidence suggests that the insect and mammalian innate immune response is mediated by h...
<p>(<b>A</b>) <i>p38c<sup>7B1</sup></i> and <i>Mekk1<sup>Ur36</sup></i> mutants accumulate lipids in...
The integrity of the intestinal epithelium is crucial for the barrier function of the gut. Replenish...
<p>(<b>A</b>) The induction of <i>Duox</i> upon <i>P. entomophila</i> infection is reduced in <i>p38...
SummaryMolecular mechanisms that concordantly regulate stress, life span, and aging remain incomplet...
NF-кB/Rel family proteins regulate genes that are critical for many cellular processes including apo...
Septic injury triggers a rapid and widespread response in Drosophila adults that involves the up-reg...
Cells commonly use multiprotein kinase cascades to signal information from the cell membrane to the ...
DUOX, a member of the NADPH oxidase family, acts as the first line of defense against enteric pathog...
<p>(<b>A</b>) Data from Flyatlas showed an enrichment of p38c in the midgut <a href="http://www.plos...
The target of rapamycin (TOR) complex 1 (TORC1) signaling pathway is a critical regulator of transla...
BackgroundFruit flies and mammals protect themselves against infection by mounting immune and metabo...
[[abstract]]Local infections can trigger immune responses in distant organs, and this interorgan imm...
[[abstract]]Local infections can trigger immune responses in distant organs, and this interorgan imm...