Nrf2 is a master regulator of oxidative stresses through the induction of anti-oxidative genes. Nrf2 plays roles in maintaining murine hematopoietic stem cells and fly intestinal stem cells. The canonical Notch signaling pathway is also crucial for maintaining several types of adult stem cells including muscle stem cells (satellite cells). Here, we show that Dll1 induced Nrf2 expression in myogenic cells. In addition, primary targets of Notch signal-ing, Hesr1 and Hesr3, were involved in the up-regulation of Nrf2 mRNA and expression of its target genes. In vitro, Nrf2 had anti-myogenic and anti-proliferative effects on primary myoblasts. In vivo, although Nrf2-knockout mice showed decreased expression of its target genes in muscle stem cell...
Muscle is an integrated tissue composed of distinct cell types and extracellular matrix. While much ...
Copyright © 2013 Eri Kobayashi et al. This is an open access article distributed under the Creative ...
Hypoxia inducible factors (HIFs) are central mediators of cellular responses to fluctuations of oxyg...
Nrf2 is a master regulator of oxidative stresses through the induction of anti-oxidative genes. Nrf2...
Satellite cells (SCs) are myogenic stem cells found in skeletal muscle that function to repair tissu...
Increased oxidative stress can slow down the regeneration of skeletal muscle and affect the activity...
Regular physical exercise is central to a healthy lifestyle. However, exercise-related muscle contra...
permits unrestricted use, distribution, and reproduction in any medium, provided the original work i...
Myogenic stem cells are a promising avenue for the treatment of muscular disorders. Freshly isolated...
International audienceMyogenic stem cells are a promising avenue for the treatment of muscular disor...
The skeletal muscle is the most abundant tissue in humans and its malfunction affects life quality. ...
Skeletal muscle regeneration provides a powerful model to study the cellular and molecular mechanism...
Somatic stem cells hold attractive potential for the treatment of muscular dystrophies (MDs). Mesoan...
Skeletal muscle redox homeostasis is transcriptionally regulated by nuclear erythroid-2-p45-related ...
Adult skeletal muscle contains a population of tissue~specific stem cells (satellite cells) that are...
Muscle is an integrated tissue composed of distinct cell types and extracellular matrix. While much ...
Copyright © 2013 Eri Kobayashi et al. This is an open access article distributed under the Creative ...
Hypoxia inducible factors (HIFs) are central mediators of cellular responses to fluctuations of oxyg...
Nrf2 is a master regulator of oxidative stresses through the induction of anti-oxidative genes. Nrf2...
Satellite cells (SCs) are myogenic stem cells found in skeletal muscle that function to repair tissu...
Increased oxidative stress can slow down the regeneration of skeletal muscle and affect the activity...
Regular physical exercise is central to a healthy lifestyle. However, exercise-related muscle contra...
permits unrestricted use, distribution, and reproduction in any medium, provided the original work i...
Myogenic stem cells are a promising avenue for the treatment of muscular disorders. Freshly isolated...
International audienceMyogenic stem cells are a promising avenue for the treatment of muscular disor...
The skeletal muscle is the most abundant tissue in humans and its malfunction affects life quality. ...
Skeletal muscle regeneration provides a powerful model to study the cellular and molecular mechanism...
Somatic stem cells hold attractive potential for the treatment of muscular dystrophies (MDs). Mesoan...
Skeletal muscle redox homeostasis is transcriptionally regulated by nuclear erythroid-2-p45-related ...
Adult skeletal muscle contains a population of tissue~specific stem cells (satellite cells) that are...
Muscle is an integrated tissue composed of distinct cell types and extracellular matrix. While much ...
Copyright © 2013 Eri Kobayashi et al. This is an open access article distributed under the Creative ...
Hypoxia inducible factors (HIFs) are central mediators of cellular responses to fluctuations of oxyg...