RESEARCH ARTICLE

ska op zk Both diabetes and immunosuppressive treatment predis- [14,15]. An impaired cellular response is also related to Olczak-Kowalczyk et al. BMC Oral Health (2015) 15:57 DOI 10.1186/s12903-015-0042-6also occur in an impaired defence mechanism and fungus-Miodowa St, 00-246 Warszawa, Poland Full list of author information is available at the end of the articlepose children to plaque-related gingivitis and oral yeast infections [1-12]. Both diseases present a number of fac-tors promoting bacterial and fungal infections. Reduced salivary flow and modified salivary composition might occur in uncompensated diabetes [13]. Neutrophil activ-ity and cell-mediated immunity are impaired. Patients with diabetes are even considered to present a modified long-term immunosuppressive treatment in Nephrotic syndrome. The syndrome (NS) is a clinical condition with a proteinuria level exceeding the body’s compensating abilities (protein loss over 50 mg/kg/day). Proteinuria re-sults in hypo- and dysproteinaemia, hyperlipidaemia, and modifications in immunoglobulin composition (including decreased IgG levels), which additionally impair the body’s immunity [16]. Candida spp. often colonises the oral cavity without presenting any lesions. However, candidiasis symptom