Add to ORKGCopyright © 2014 Vikram Bhatia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Promoter methylation and relative gene expression of O6-methyguanine-DNA-methyltransferase (MGMT) and p16 genes were examined in tissue and blood samples of patients with premalignant oral lesions (PMOLs) and oral squamous cell carcinoma (OSCC). Methylation-specific PCR and reverse transcriptase PCR were performed in 146 tissue and blood samples from controls and patients with PMOLs and OSCC. In PMOL group, significant promoter methylation of MGMT and p16 genes was observe
Epigenetic factors play a fundamental role in the etiopathogenesis of oral squamous cell carcinoma (...
Apart from genetic mutation, DNA methylation, an epigenetic event, has emerged as an important genom...
Oral squamous cell carcinoma (OSCC) is a malignant disease. Methylation plays a key role in the etio...
Promoter methylation and relative gene expression of O6-methyguanine-DNA-methyltransferase (MGMT) an...
AbstractBackground/purposeOral squamous cell carcinoma (OSCC) is the fourth major cause of mortality...
Background: Hypermethylation in promoter regions of genes might lead to altered gene functions and r...
Epigenetic silencing of the p16 and p15 genes by promoter methylation are commonly observed in human...
Mingli Liu1, Lei Feng2, Ximing Tang3, Shanchun Guo41Department of Physics, Tufts University School o...
Genetic polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) enzyme may influence DNA me...
We evaluated promoter hypermethylation of a panel of tumor suppressor genes as a means to detect epi...
ntroduction: DNA methylation is an epigenetic phenomenon at molecular level that involves gene expre...
Background Epigenetic and genetic alteration plays a major role to the development of head and neck ...
Copyright © 2013 Kimiko Ishiguro et al. This is an open access article distributed under the Creativ...
Head and neck cancers (HNCs) represent a significant and ever-growing burden to the modern society, ...
Objective. To investigate the prevalence of p16(INK4) (a), p14(ARF), tumor protein p53 (TP53), and h...
Epigenetic factors play a fundamental role in the etiopathogenesis of oral squamous cell carcinoma (...
Apart from genetic mutation, DNA methylation, an epigenetic event, has emerged as an important genom...
Oral squamous cell carcinoma (OSCC) is a malignant disease. Methylation plays a key role in the etio...
Promoter methylation and relative gene expression of O6-methyguanine-DNA-methyltransferase (MGMT) an...
AbstractBackground/purposeOral squamous cell carcinoma (OSCC) is the fourth major cause of mortality...
Background: Hypermethylation in promoter regions of genes might lead to altered gene functions and r...
Epigenetic silencing of the p16 and p15 genes by promoter methylation are commonly observed in human...
Mingli Liu1, Lei Feng2, Ximing Tang3, Shanchun Guo41Department of Physics, Tufts University School o...
Genetic polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) enzyme may influence DNA me...
We evaluated promoter hypermethylation of a panel of tumor suppressor genes as a means to detect epi...
ntroduction: DNA methylation is an epigenetic phenomenon at molecular level that involves gene expre...
Background Epigenetic and genetic alteration plays a major role to the development of head and neck ...
Copyright © 2013 Kimiko Ishiguro et al. This is an open access article distributed under the Creativ...
Head and neck cancers (HNCs) represent a significant and ever-growing burden to the modern society, ...
Objective. To investigate the prevalence of p16(INK4) (a), p14(ARF), tumor protein p53 (TP53), and h...
Epigenetic factors play a fundamental role in the etiopathogenesis of oral squamous cell carcinoma (...
Apart from genetic mutation, DNA methylation, an epigenetic event, has emerged as an important genom...
Oral squamous cell carcinoma (OSCC) is a malignant disease. Methylation plays a key role in the etio...