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Recently, several articles have been pub-lished questioning the usefulness of animal experiments for prediction of human toxicity (Leist and Hartung, 2013). For example, it has been reported that there is almost no cor-relation of gene expression alterations in-duced by inflammatory stimuli in humans and mice (Seok et al., 2013). However, a re-cent study of Thiel et al. (2015) demonstrates that this view may be too pessimistic. Based on pharmacokinetic modeling, Thiel et al. (2015) demonstrated a surprisingly precise mouse to human extrapolation for 10 exem-plary pharmaceuticals. For interspecies mod-eling the authors adjusted four paramete