Original Article Molecular Imaging and Radionuclide Therapy 2011;20(1): 7-13 DOI: 10.4274/MIRT.20.02

Objective: The aim of this prospective study was to evaluate the additional value of Tc 99m HMPAO white blood cell (WBC) SPECT for bone and soft tissue infections. Materials and Methods: Thirty-eight patients with suspected bone and joint infection were included in the study. Patients were assigned into 2 groups according to the presence of orthopedic implants. All patients had multiphase bone scan (BS) with Tc 99m methylene diphosphonate and WBC scintigraphy. The planar images of BS and WBC images were evaluated together. SPECT WBC images were evaluated separately. Results: Group 1 had 30 patients including 12 patients with diabetic foot, 17 patients with suspected relapse of chronic osteomyelitis and 1 with septic arthritis. In 19 of 30 patients, BS and planar WBC images were similar with SPECT images in terms of final diagnosis. In the remain-ing 11 patients, planar BS+planar WBC images and SPECT WBC images were discordant. Group 2 included 8 patients with suspected infection of orthopedic implants. There was no difference between planar BS+planar WBC images and SPECT WBC in 6 of 8 patients. SPECT WBC images changed the diagnosis of 13 (34.2%) patients in the whole group. SPECT WBC images did not have any contribution in the evaluation of the 6 patients who had reactive changes. Conclusion: SPECT images made significant contribution in discriminating soft tissue infection from osteomyelitis and improved diagnosis in terms of localization and the extent of disease. (MIRT 2011; 20: 7-13