RESEARCH ARTICLE Tanshinone IIA pretreatme u

Full list of author information is available at the end of the articleBackground Flaps are routinely used in plastic surgery for covering tissue defects resulting from trauma, ablative surgery, or congenital malformation, although partial or total flap necrosis after flap surgery is not uncommon [1,2]. The transplantation of marrow mesenchymal cells [3] and adipose-derived stem cells [4] is effective in regenerating tissue, and Yi et al. [5] report that vascular endothelial growth factor (VEGF) gene therapy can enhance the sur-vival and quality of grafted fat tissue in nude mice. It is also reported that hyperbaric O2 is clinically effective as an adjuvant therapy for improving wound healing and neovascularization and attenuating oxidative stress [6]. At the same time, however, there are still clear potential disadvantages of these treatment strategies. Considering * Correspondence