Add to ORKGDiscriminating pathogenic bacteria from bacteria used as a food source is key to Caenorhabidits elegans immunity. Using mutants defective in the enzymes of O-linked N-acetylglucosamine (O-GlcNAc) cycling, we examined the role of this nutrient-sensing pathway in the C. elegans innate immune response. Genetic analysis showed that deletion of O-GlcNAc transferase (ogt-1) yielded animals hypersensitive to the human pathogen S. aureus but not to P. aeruginosa. Genetic interaction studies revealed that nutrient-responsive OGT-1 acts through the conserved b-catenin (BAR-1) pathway and in concert with p38 MAPK (PMK-1) to modulate the immune response to S. aureus. Moreover, whole genome transcriptional profiling revealed that O-GlcNAc cycling mutant...
In C. elegans, 283 clec genes encode a highly diverse family of C-type lectin-like domain (CTLD) pro...
International audienceBackground: Caenorhabditis elegans has emerged over the last decade as a usefu...
<p>Recently, the study of invertebrate innate immunity has garnered considerable attention after the...
Discriminating pathogenic bacteria from bacteria used as a food source is key to Caenorhabidits eleg...
<div><p>Discriminating pathogenic bacteria from bacteria used as a food source is key to <i>Caenorha...
GATA transcription factors play critical roles in cellular differentiation and development. However,...
International audienceABSTRACT: BACKGROUND: There are striking similarities between the innate immun...
<p>An estimated twenty-five percent of the fifty-seven million annual deaths worldwide can be direct...
The oligosaccharyl transferase (OST) protein complex mediates the N-linked glycosylation of substrat...
Free-living nematodes such as C. elegans and P. pacificus encounter a variety of bacteria in their n...
The mitochondrial unfolded protein response (UPRmt) is a promising pharmacological target for aging ...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2018.This electronic v...
The bacterivorous nematode Caenorhabditis elegans is an excellent model for the study of innate immu...
Microbial pathogens impose selective pressures on their hosts, and combatting these path-ogens is fu...
The nematode Caenorhabditis elegans offers currently untapped potential for carrying out high-throug...
In C. elegans, 283 clec genes encode a highly diverse family of C-type lectin-like domain (CTLD) pro...
International audienceBackground: Caenorhabditis elegans has emerged over the last decade as a usefu...
<p>Recently, the study of invertebrate innate immunity has garnered considerable attention after the...
Discriminating pathogenic bacteria from bacteria used as a food source is key to Caenorhabidits eleg...
<div><p>Discriminating pathogenic bacteria from bacteria used as a food source is key to <i>Caenorha...
GATA transcription factors play critical roles in cellular differentiation and development. However,...
International audienceABSTRACT: BACKGROUND: There are striking similarities between the innate immun...
<p>An estimated twenty-five percent of the fifty-seven million annual deaths worldwide can be direct...
The oligosaccharyl transferase (OST) protein complex mediates the N-linked glycosylation of substrat...
Free-living nematodes such as C. elegans and P. pacificus encounter a variety of bacteria in their n...
The mitochondrial unfolded protein response (UPRmt) is a promising pharmacological target for aging ...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2018.This electronic v...
The bacterivorous nematode Caenorhabditis elegans is an excellent model for the study of innate immu...
Microbial pathogens impose selective pressures on their hosts, and combatting these path-ogens is fu...
The nematode Caenorhabditis elegans offers currently untapped potential for carrying out high-throug...
In C. elegans, 283 clec genes encode a highly diverse family of C-type lectin-like domain (CTLD) pro...
International audienceBackground: Caenorhabditis elegans has emerged over the last decade as a usefu...
<p>Recently, the study of invertebrate innate immunity has garnered considerable attention after the...