Penile squamous cell carcinoma (PeCa) is a rare malignancy and little is known regarding the molecular mechanisms involved in carcinogenesis of PeCa. TheWnt signaling path-way, with the transcription activator ß-catenin as a major transducer, is a key cellular path-way during development and in disease, particularly cancer. We have used PeCa tissue arrays and multi-fluorophore labelled, quantitative, immunohistochemistry to interrogate the expression of WNT4, a Wnt ligand, and three targets of Wnt-ß-catenin transcription activa-tion, namely, MMP7, cyclinD1 (CD1) and c-MYC in 141 penile tissue cores from 101 unique samples. The expression of all Wnt signaling proteins tested was increased by 1.6 to 3 fold in PeCa samples compared to control ...
Background: Penile carcinoma (PeCa) is frequently associated with high morbidity rates. Unlikely of ...
Cataloged from PDF version of article.Wnt signaling is involved in a large set of cellular and devel...
Background: Despite penile carcinoma (PeCa) being a relatively rare neoplasm, it remains an importan...
Penile squamous cell carcinoma (PeCa) is a rare malignancy and little is known regarding the molecul...
Penile squamous cell carcinoma (PeCa) is a rare malignancy and little is known regarding the molecul...
Penile cancer (PeCa) is a rare malignancy with potentially devastating effects. Squamous cell carcin...
Aims: Signalling through the Wnt pathway is integrally associated with colon carcinogenesis. Althoug...
Pancreatic adenocarcinoma (PA) is among the most aggressive human tumors with an overall 5-year surv...
Penile cancer (PeCa) is a relatively rare tumor entity but possesses higher morbidity and mortality ...
Autocrine activation of the Wnt/b-catenin pathway occurs in several cancers, notably in breast tumor...
Our previous data illustrated that activation of the canonical Wnt signaling pathway was en-riched i...
Penile carcinoma (PeCa) represents an important public health problem in poor and developing countri...
Despite decades of effort to develop effective therapy and to identify promising new drugs, prostate...
an ian Background Colorectal cancer (CRC) is the second most common result in hyperactivation of the...
AIMS: The aim of this study was to evaluate the immunohistochemical expression of mammalian target o...
Background: Penile carcinoma (PeCa) is frequently associated with high morbidity rates. Unlikely of ...
Cataloged from PDF version of article.Wnt signaling is involved in a large set of cellular and devel...
Background: Despite penile carcinoma (PeCa) being a relatively rare neoplasm, it remains an importan...
Penile squamous cell carcinoma (PeCa) is a rare malignancy and little is known regarding the molecul...
Penile squamous cell carcinoma (PeCa) is a rare malignancy and little is known regarding the molecul...
Penile cancer (PeCa) is a rare malignancy with potentially devastating effects. Squamous cell carcin...
Aims: Signalling through the Wnt pathway is integrally associated with colon carcinogenesis. Althoug...
Pancreatic adenocarcinoma (PA) is among the most aggressive human tumors with an overall 5-year surv...
Penile cancer (PeCa) is a relatively rare tumor entity but possesses higher morbidity and mortality ...
Autocrine activation of the Wnt/b-catenin pathway occurs in several cancers, notably in breast tumor...
Our previous data illustrated that activation of the canonical Wnt signaling pathway was en-riched i...
Penile carcinoma (PeCa) represents an important public health problem in poor and developing countri...
Despite decades of effort to develop effective therapy and to identify promising new drugs, prostate...
an ian Background Colorectal cancer (CRC) is the second most common result in hyperactivation of the...
AIMS: The aim of this study was to evaluate the immunohistochemical expression of mammalian target o...
Background: Penile carcinoma (PeCa) is frequently associated with high morbidity rates. Unlikely of ...
Cataloged from PDF version of article.Wnt signaling is involved in a large set of cellular and devel...
Background: Despite penile carcinoma (PeCa) being a relatively rare neoplasm, it remains an importan...
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