Research Article Decreased IL-27 Negatively Correlated with Th17 Cells in Non-Small-Cell Lung Cancer Patients

Copyright © 2015 Minchao Duan et al.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The presence of Th17 cells and IL-27 is observed in a variety of inflammatory associated cancers. However, there are some data on the role ofTh17 cells and IL-27 in the regulation of immune reactions in non-small-cell lung cancer (NSCLC).The aim of this study is to assess the variation ofTh17 cells and IL-27 in the peripheral blood (PB) of patients with NSCLC.The proportion ofTh17 cells in peripheral blood mononuclear cells (PBMCs) was evaluated by flow cytometry. The serum concentrations of IL-27 and IL-17 were measured by enzyme-linked immunosorbent assay (ELISA). The mRNA expression of RO