Research Article Antihyperglycemic Effect of Ginkgo biloba Extract in Streptozotocin-Induced Diabetes in Rats

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. e Ginkgo biloba extract (GBE) has been reported to have a wide range of health bene�ts in traditional Chinese medicine. e aim of this study was to evaluate the antihyperglycemic effects of GBE on streptozotocin- (STZ-) induced diabetes in rats. Diabetes was induced in male Wistar rats by the administration of STZ (60mg/kg b.w.) intraperitoneally. GBE (100, 200, and 300mg/kg b.w.) was administered orally once a day for a period of 30 days. Body weight and blood glucose levels were determined in different experimental days. Serum lipid pro�le and antioxidant enzymes in hepatic and pancreatic tissue were measured at the end of the experimental period. Signi�cant decreases in body weight and antioxidant ability and increases in blood glucose, lipid pro�le, and lipid peroxidation were observed in STZ-induced diabetic rats. e administration of GBE and glibenclamide daily for 30 days in STZ-induced diabetic rats reversed the above parameters signi�cantly. GBE possesses antihyperglycemic, antioxidant, and antihyperlipidemia activities in STZ-induced chronic diabetic rats, which promisingly support the use of GBE as a food supplement or an adjunct treatment for diabetics. 1