Open AcceReview Current indications for post-mastectomy radiation

It has been long established that post-mastectomy radiotherapy reduces the risk of locoregional failure. A survival advantage, however, has only recently been demonstrated. We here provide a review of the literature as regards to the current indications for post-mastectomy radiotherapy. Current indications for post-mastectomy radiation Primary breast carcinoma may be managed surgically with either mastectomy or breast conserving surgery. Although radiotherapy following breast conserving surgery is widely accepted, the role of post-mastectomy radiotherapy (PMRT) has been a subject for debate for many years. PMRT has been known since the 1970's to substantially reduce the risk of locoregional failure (LRF), however, a disease specific survival and overall survival advantage has only more recently been demonstrated [1-5]. The systemi