Add to ORKGnon-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Genome-wide association studies (GWAS) have identified specific common genetic variants within a region on the long arm of chromosome 15 (15q25) as risk factors for lung cancer (1–3) and other smoking-related health outcomes, such as chronic obstruc-tive pulmonary disease (4,5), peripheral arterial disease (3,6), low birth weight in offspring (7), and lower body mass index (8). This region contains the a5, a3, and b4 nicotinic acetylcholine receptor subunit gene cluster, CHRNA5-CHRNA3-CHRNB4 (CHRNA5-A3-B4); although most studies to date have focused on the rs16969968 and rs1051730 single-nucleotide polymorphisms (SNPs) within this...
LetterInternational audienceLung cancer is the most common cause of cancer death worldwide, with ove...
Background: Genetic variants in 15q25 have been identified as potential risk markers for lung cancer...
Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKlin...
non-commercial use, distribution, and reproduction in any medium, provided the original work is prop...
non-commercial use, distribution, and reproduction in any medium, provided the original work is prop...
Recently, genetic association findings for nicotine dependence, smoking behavior, and smoking-relate...
Recently, genetic association findings for nicotine dependence, smoking behavior, and smoking-relate...
Cigarette smoking is one of the major risk factors for COPD and COPD severity. In turn COPD is a maj...
Genetic variants at the 15q25 CHRNA5-CHRNA3 locus have been shown to influence lung cancer risk howe...
Introduction:Three genome-wide association studies identified a region on chromosome 15q25.1 associa...
<div><p>Introduction</p><p>Recently, genome-wide association studies (GWAS) in Caucasian populations...
INTRODUCTION:Recently, genome-wide association studies (GWAS) in Caucasian populations have identifi...
Abstract: Lung cancer is the most common cause of cancer death worldwide, with over one million case...
Genome-wide association studies have identified variants on chromosome 15q25.1 that increase the ris...
LetterInternational audienceLung cancer is the most common cause of cancer death worldwide, with ove...
Background: Genetic variants in 15q25 have been identified as potential risk markers for lung cancer...
Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKlin...
non-commercial use, distribution, and reproduction in any medium, provided the original work is prop...
non-commercial use, distribution, and reproduction in any medium, provided the original work is prop...
Recently, genetic association findings for nicotine dependence, smoking behavior, and smoking-relate...
Recently, genetic association findings for nicotine dependence, smoking behavior, and smoking-relate...
Cigarette smoking is one of the major risk factors for COPD and COPD severity. In turn COPD is a maj...
Genetic variants at the 15q25 CHRNA5-CHRNA3 locus have been shown to influence lung cancer risk howe...
Introduction:Three genome-wide association studies identified a region on chromosome 15q25.1 associa...
<div><p>Introduction</p><p>Recently, genome-wide association studies (GWAS) in Caucasian populations...
INTRODUCTION:Recently, genome-wide association studies (GWAS) in Caucasian populations have identifi...
Abstract: Lung cancer is the most common cause of cancer death worldwide, with over one million case...
Genome-wide association studies have identified variants on chromosome 15q25.1 that increase the ris...
LetterInternational audienceLung cancer is the most common cause of cancer death worldwide, with ove...
Background: Genetic variants in 15q25 have been identified as potential risk markers for lung cancer...
Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKlin...