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In this paper, we propose a multiscale empirical interpolation method for solving nonlinear multiscale partial differential equations. The proposed method combines empirical interpola-tion techniques and local multiscale methods, such as the Generalized Multiscale Finite Element Method (GMsFEM). To solve nonlinear equations, the GMsFEM is used to represent the solution on a coarse grid with multiscale basis functions computed offline. Computing the GMsFEM solu-tion involves calculating the residuals on the fine grid. We use empirical interpolation concepts to evaluate the residuals and the Jacobians of the multiscale system with a computational cost which is proportional to the coarse scale problem rather than the fully-resolved fine scale one. Empirical interpolation methods use basis functions and an inexpensive inversion which are computed in the offline stage for finding the coefficients in the expansion based on a limited number of nonlinear function evaluations. The proposed multiscale empirical interpolation techniques: (1) divide com-puting the nonlinear function into coarse regions; (2) evaluate contributions of nonlinear functions in each coarse region taking advantage of a reduced-order representation of the solution; and (3) introduce multiscale proper-orthogonal-decomposition techniques to find appropriate interpolation vectors. We demonstrate the effectiveness of the proposed methods on several examples of non-linear multiscale PDEs that are solved with Newton’s methods and fully-implicit time marchin