Agent-based exploration of wiring of biological neural networks: Position paper

The understanding of human central nervous system (CNS) depends on knowledge of its wiring. However, there are still gaps in our understanding of its wiring due to technical difficulties. While some information is com-ing out from human experiments, medical research is lacking of simulation models to put current findings together to obtain the global picture and to predict hypotheses to lead future experiments. Agent-based mod-eling and simulation (ABMS) is a strong can-didate for the simulation model. In this po-sition paper, we discuss the current status of “neural wiring ” and “ABMS in biological sys-tems”. In particular, the paper discusses that the ABMS context provides features that re-quire for exploration of wiring of biological neural networks.