Cycling tissues such as the intestinal epithelium, germ line, and hair follicles, require a constant flux of differentiated cells. These tissues are maintained by a population of stem cells, which generate differentiated progenies and self-renew. Asymmetric division of each stem cell into one stem cell and one differentiated cell can accomplish both tasks. However, in mammalian cycling tissues, some stem cells divide symmetrically into two differentiated cells and are replaced by a neighbor that divides symmetrically into two stem cells. Besides this heterogeneity in fate (population asymmetry), stem cells also exhibit heterogenous proliferation-rates; in the long run, however, all stem cells proliferate at the same average rate (equipotenc...
The asymmetric distribution of damaged cellular components has been observed in species ranging from...
<p>(A) Homeostasis of stem cell number may be achieved by invariant asymmetric renewals. (B) Alterna...
To maintain cycling adult tissue in homeostasis the balance between proliferation and differentiatio...
Traditionally, it has been held that a central characteristic of stem cells is their ability to divi...
Traditionally, it has been held that a central characteristic of stem cells is their ability to divi...
Stem cell divisions are either asymmetric-in which one daughter cell remains a stem cell and one doe...
<div><p>In multi-cellular organisms, tissue homeostasis is maintained by an exquisite balance betwee...
In cycling tissues that exhibit high turnover, tissue maintenance and repair are coordinated by stem...
Most tissues in metazoans undergo continuous turnover due to cell death or epithelial shedding. Sinc...
Stem cells are defined by both their ability to make more stem cells, a property known as 'self...
Stem cell divisions are either asymmetric—in which one daughter cell remains a stem cell and one doe...
In multi-cellular organisms, tissue homeostasis is maintained by an exquisite balance between stem c...
Most tissues in metazoans undergo continuous turnover due to cell death or epithelial shedding. Sinc...
Much has been made of the idea that asymmetric cell division is a defining characteristic of stem ce...
Stem cells, with their capacity to self-renew and to differentiate to more specialized cell types, p...
The asymmetric distribution of damaged cellular components has been observed in species ranging from...
<p>(A) Homeostasis of stem cell number may be achieved by invariant asymmetric renewals. (B) Alterna...
To maintain cycling adult tissue in homeostasis the balance between proliferation and differentiatio...
Traditionally, it has been held that a central characteristic of stem cells is their ability to divi...
Traditionally, it has been held that a central characteristic of stem cells is their ability to divi...
Stem cell divisions are either asymmetric-in which one daughter cell remains a stem cell and one doe...
<div><p>In multi-cellular organisms, tissue homeostasis is maintained by an exquisite balance betwee...
In cycling tissues that exhibit high turnover, tissue maintenance and repair are coordinated by stem...
Most tissues in metazoans undergo continuous turnover due to cell death or epithelial shedding. Sinc...
Stem cells are defined by both their ability to make more stem cells, a property known as 'self...
Stem cell divisions are either asymmetric—in which one daughter cell remains a stem cell and one doe...
In multi-cellular organisms, tissue homeostasis is maintained by an exquisite balance between stem c...
Most tissues in metazoans undergo continuous turnover due to cell death or epithelial shedding. Sinc...
Much has been made of the idea that asymmetric cell division is a defining characteristic of stem ce...
Stem cells, with their capacity to self-renew and to differentiate to more specialized cell types, p...
The asymmetric distribution of damaged cellular components has been observed in species ranging from...
<p>(A) Homeostasis of stem cell number may be achieved by invariant asymmetric renewals. (B) Alterna...
To maintain cycling adult tissue in homeostasis the balance between proliferation and differentiatio...