Add to ORKGABSTRACT. It has recently been noted that the relative prevalence of the various kinds of epistasis varies along an adaptive walk. This has been explained as a result of mean regression in NK model fitness landscapes. Here we show that this phenomenon occurs quite generally in fitness landscapes. We propose a simple and general explanation for this phenomenon, confirming the role of mean regression. We provide support for this explanation with simulations, and discuss the empirical relevance of our findings
The contribution to an organism's phenotype from one genetic locus may depend upon the status of oth...
Fitness landscapes map genotypes to their corresponding fitness under given environments and allow e...
Evolution is an incredibly complex process that has been the subject of scientific study for well ov...
<div><p>It has recently been noted that the relative prevalence of the various kinds of epistasis va...
Epistasis occurs when the effect of a mutation depends on its carrier's genetic background. Despite ...
The role that epistasis plays during adaptation remains an outstanding problem, which has received c...
The role that epistasis plays during adaptation remains an outstanding problem, which has received c...
Fitness landscapes are the invisible force responsible for directing the course of evolution. Here, ...
The average fitness difference between adjacent sites in a fitness landscape is an important descrip...
In our simulations, the initial fitness of each block is chosen independently such that their averag...
We study the adaptation dynamics of a maladapted asexual population on rugged fitness landscapes wit...
International audienceThe fitness landscapethe mapping between genotypes and fitnessdetermines prope...
The concept of a fitness landscape is a powerful metaphor that offers insight into various aspects o...
<p>Ruggedness (A), correlation length (B), and neutrality (C) as a function of the magnitude of epis...
Fitness landscapes determine the course of adaptation by constraining and shaping evolutionary traje...
The contribution to an organism's phenotype from one genetic locus may depend upon the status of oth...
Fitness landscapes map genotypes to their corresponding fitness under given environments and allow e...
Evolution is an incredibly complex process that has been the subject of scientific study for well ov...
<div><p>It has recently been noted that the relative prevalence of the various kinds of epistasis va...
Epistasis occurs when the effect of a mutation depends on its carrier's genetic background. Despite ...
The role that epistasis plays during adaptation remains an outstanding problem, which has received c...
The role that epistasis plays during adaptation remains an outstanding problem, which has received c...
Fitness landscapes are the invisible force responsible for directing the course of evolution. Here, ...
The average fitness difference between adjacent sites in a fitness landscape is an important descrip...
In our simulations, the initial fitness of each block is chosen independently such that their averag...
We study the adaptation dynamics of a maladapted asexual population on rugged fitness landscapes wit...
International audienceThe fitness landscapethe mapping between genotypes and fitnessdetermines prope...
The concept of a fitness landscape is a powerful metaphor that offers insight into various aspects o...
<p>Ruggedness (A), correlation length (B), and neutrality (C) as a function of the magnitude of epis...
Fitness landscapes determine the course of adaptation by constraining and shaping evolutionary traje...
The contribution to an organism's phenotype from one genetic locus may depend upon the status of oth...
Fitness landscapes map genotypes to their corresponding fitness under given environments and allow e...
Evolution is an incredibly complex process that has been the subject of scientific study for well ov...