available at the end of the article Background: PLINK 1 is a widely used open-source C/C++ toolset for genome-wide association studies (GWAS) and research in population genetics. However, the steady accumulation of data from imputation and whole-genome sequencing studies has exposed a strong need for even faster and more scalable implementations of key functions. In addition, GWAS and population-genetic data now frequently contain probabilistic calls, phase information, and/or multiallelic variants, none of which can be represented by PLINK 1’s primary data format. Findings: To address these issues, we are developing a second-generation codebase for PLINK. The first major release from this codebase, PLINK 1.9, introduces extensive use of bi...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
Motivation: The declining cost of generating DNA sequence is pro-moting an increase in whole genome ...
Advancements in technologies have resulted in an explosion of data, the volume of which continues to...
Background: PLINK 1 is a widely used open-source C/C++ toolset for genome-wide association studies (...
Background: PLINK 1 is a widely used open-source C/C++ toolset for genome-wide association studies (...
Whole-genome association studies (WGAS) bring new computational, as well as analytic, challenges to ...
Whole-genome association studies (WGAS) bring new computational, as well as analytic, challenges to ...
Whole-genome association studies (WGAS) bring new computational, as well as analytic, challenges to ...
Background: As sequencing technologies can help researchers detect common and rare variants across t...
Next generation sequencing (NGS) has been a great success and is now a standard meth-od of research ...
Summarization: Positive selection is the tendency of beneficial traits to increase in prevalence in ...
<p>Ensembl already provides a genome browser where the 1000 Genomes Project data can be viewed by an...
BACKGROUND: Polygenic risk score (PRS) analyses have become an integral part of biomedical research,...
Next-generation sequencing (NGS) has revolutionized genetics and enabled the accurate identification...
The impending advent of population-scaled sequencing cohorts involving tens of millions of individua...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
Motivation: The declining cost of generating DNA sequence is pro-moting an increase in whole genome ...
Advancements in technologies have resulted in an explosion of data, the volume of which continues to...
Background: PLINK 1 is a widely used open-source C/C++ toolset for genome-wide association studies (...
Background: PLINK 1 is a widely used open-source C/C++ toolset for genome-wide association studies (...
Whole-genome association studies (WGAS) bring new computational, as well as analytic, challenges to ...
Whole-genome association studies (WGAS) bring new computational, as well as analytic, challenges to ...
Whole-genome association studies (WGAS) bring new computational, as well as analytic, challenges to ...
Background: As sequencing technologies can help researchers detect common and rare variants across t...
Next generation sequencing (NGS) has been a great success and is now a standard meth-od of research ...
Summarization: Positive selection is the tendency of beneficial traits to increase in prevalence in ...
<p>Ensembl already provides a genome browser where the 1000 Genomes Project data can be viewed by an...
BACKGROUND: Polygenic risk score (PRS) analyses have become an integral part of biomedical research,...
Next-generation sequencing (NGS) has revolutionized genetics and enabled the accurate identification...
The impending advent of population-scaled sequencing cohorts involving tens of millions of individua...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
Motivation: The declining cost of generating DNA sequence is pro-moting an increase in whole genome ...
Advancements in technologies have resulted in an explosion of data, the volume of which continues to...