Abstract—Gaussian and quadratic approximations of message passing algorithms on graphs have attracted considerable recent attention due to their computational simplicity, analytic tractabil-ity, and wide applicability in optimization and statistical inference problems. This paper presents a systematic framework for incor-porating such approximate message passing (AMP) methods in general graphical models. The key concept is a partition of depen-dencies of a general graphical model into strong and weak edges, with the weak edges representing interactions through aggregates of small, linearizable couplings of variables. AMP approximations based on the Central Limit Theorem can be readily applied to the weak edges and integrated with standard m...