Abstract We report on progress towards implement-ing mixed ion species quantum information process-ing for a scalable ion trap architecture. Mixed species chains may help solve several problems with scaling ion trap quantum computation to large numbers of qubits. Initial temperature measurements of linear Coulomb crystals containing barium and ytterbium ions indicate that the mass difference does not significantly impede cooling at low ion numbers. Average motional occupa-tion numbers are estimated to be n ̄ ≈ 130 quanta per mode for chains with small numbers of ions, which is within a factor of three of the Doppler limit for bar-ium ions in our trap. We also discuss generation of ion-photon entanglement with barium ions with a fidelity of...