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Abstract: We prove a generalization of the Conley conjecture: Every Hamil-tonian diffeomorphism of a closed symplectic manifold has infinitely many periodic orbits if the first Chern class vanishes over the second fundamental group. In partic-ular, this removes the rationality condition from similar theorems by Ginzburg and Gürel. The proof in the irrational case involves several new ingredients including the definition and the properties of the filtered Floer homology for Hamiltonians on irrational manifolds. We also develop a method of localizing the filtered Floer homology for short action intervals using a direct sum decomposition, where one of the summands only depends on the behavior of the Hamiltonian in a fixed ope