EFFECTS ON RENAL GRAFT FUNCTION IN EARLY POSTTRANSPLANT PERIOD

All conventional immunosuppressive tree drugs-protocols are based on Cyclosporine; consisting of low doses of Cyclosporine (CsA), Azathioprine (AZA) or Mycophenolate Mofetil (MMF) and Prednisolone. AZA has been used in clinical transplantation for more than years and was the fi rst immunosuppres-sive agent to achieve widespread use in organ transplantation. MMF was introduced in clinical practice in after several clinical trials proved that it was more effi cient than AZA for prevention of acute rejection episodes. Our aim was to evaluate infl uence of AZA and MMF on renal graft function in early post-transplant stage. Study recruited patients who underwent kidney transplantation in University Clinical Centre Tuzla. All patients received CsA and corticosteroid-based immunosuppression, as a part of triple immunosuppressive regiment, patients received AZA and MMF. In order to assess renal graft function, following parameters were evaluated: glomerular fi ltration rate GFR (ml/min) creatinine clearance (CrCl) (ml/min), h urine output (ml/day), and from the serum potassium, sodium, urea and creatinine (mmol/dm). Signifi cantly higher average values of hour urine output were recorded during fi rst seven postoperative days in patients receiving MMF compared to those treated with AZA. Serum creatinine values showed statistically signifi cant decrease, starting with the second postoperativ