TABLETS

Tablets are one of the most popular and preferred solid dosage forms because they can be accu-rately dosed, easily manufactured and packaged on a large scale, have good physical and chemi-cal stability, and can contribute to good patient compliance given their ease of administration. Th e ability to match doses to patients depends on the availability of multiple dose sizes and ad-equate dose-response information. Th ese are not always provided, so splitting of the tablets is sometimes necessary. Tablet splitting is an accepted practice in dispensing medication. It has been used when a dosage form of the required strength is not available commercially. Th e aim of our study was to compare some physical parameters of whole and scored lisinopril and lisino-pril/hydrochlorthiazide tablets and to accept or exclude their infl uence on the obtaining of re-quired dosage. According to the results obtained, we may conclude that tablets from batch “I”, “II”, “III ” and “IV” satisfi ed pharmacopeial requirements concerning crushing strength, friability, disintegration time and mass uniformity. Th e hardness testing showed acceptable reproducibility and indicate that the data variation was primarily from the irreversible changes in the structure of tablet sam-ples. Th e act of compacting powders stores energy within the tablets, by shifting or compressing the intermolecular bonds within the particles. Th e tablets have a natural tendency to relax once pressure is removed, and this tendency works against the interparticle bonding formed during compression. Hardness testing procedure causes irreversible changes in this structure