Correlation Between

A characteristic feature of many cancer types is their ability to metastasise to the skeleton. Bone is the most common site of metastatic invasion, after hematogenous spreading of breast cancer. Early detection of bone metastases is mandatory in the evaluation and managament of these patients. Bone scintigraphy is commonly performed in detection and evaluation bone metastases. Tumor markers are present in healthy individuals as well as in patients with ma-lignant diseases but in different concentration. Aim of study was to correlate serum levels of tumor marker Ca - ,CEA and presence of bone metastases detected by bone scintigraphy. Study included patients with breast cancer, previously surgically treated. All patients under-went whole body scintigraphy. Ca - and CEA was measured by radioimmunoassay. Pres-ence, number of bone metastases were correlated with Ca - and CEA levels. Median age of patients included in study was varying from to . Bone scintigraphy revealed bone metastases in () patients. A weak correlation was found between number of metasta-ses and level of Ca - (r=,, p=,). Significant differences in Ca - level was found in patient with metastases compared to patients without metastases (chi square , p=,). Goo