Electrophysiological Eff ects of Bosentan in Rats with Induced Cerebral Ischemia-Reperfusion

We examined the eff ect of bosentan, an ETA and ETB receptor antagonist, on EEG, an indicator of neuronal activity, in rats with experimen-tally induced cerebral ischemia-reperfusion. Th e rats were divided into three groups with seven rats in each group. Before the procedures, the EEGs of all rats were recorded for ten minutes. mg/kg bosentan in cc physiological serum was administered to the fi rst group, and the second and third groups were injected with cc physiological serum intraperitoneally. After the administration, the right and the left common carotid arteries of the animals in Groups and were clipped for minutes using aneurysm clippings. Th e rats in the third group received only a subcutaneous incision. Ten minutes after the clips were removed in the fi rst and second groups and after the incision in the third group, EEG recordings were repeated for minutes. All the rats were decapitated and MDA values in the brain tissue were measured for evaluation of the effi ciency of induced cerebral ischemia. Induced cerebral ischemia was performed eff ectively because the MDA levels in Groups and were elevated, compared to the levels in Group (p<.). After the application of the Cerebral Ischemia-Reperfusion Technique, the EEG showed minimal slowing in the rats in Group , and generalized diff use slowing in the rats in Group compared to pre-ischemic fi ndings. Bosentan may reduce the damage induced by ischemia on neuronal electrophysiology, likely through its vasodilation eff ect on cerebral vessels