BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES 2010; 10 (3): 265-269

< e aim of our study was to compeer levels of antioxidative agent –total SH groups and the fi-nale product of lipid peroxidation- malondialdehyde (MDA) in serum, and glutathione (GSH) and MDA in nucleocortical parts of lens after extracapsular extraction of cataract. Patient were ( with cataract and controls) matched by sex and years of life. Diagnosis of cataract was established by complete ocular examination. All results are expressed as mean ± S.D. A Student’s t-test was used to estimate diff erences between the groups. < e level of signifi cance was p<,. Total sulfhydryl groups were determined in serum by the method of Ellman as well as GSH content in nucleocortical parts of lenses using the method of Sedlak and Lind-say. Lipid peroxidation, evidenced by formation of thiobarbituric acid reactive substances (TBARS), was determined in nucleocortical parts of the lens and in serum. Our results show a statistical signifi cance in concentration of total SH groups (,±,µmol/L, controls ,±,µmol/L p<,) and MDA (,±,, and controls ,±,µmol/L, p<,) in serum among patients with age related cataract and controls. < ere was no statistical signif-icance in concentration of total SH groups and MDA in serum among patients with diff eren