Drugs factory-Bosnalijek-Sarajevo, Bosnalijek dd,

Actions of acetylcholine (ACh), histamines, serotonins (-HT) and prostaglandins (PGF-alfa) in con-centrations of -, -, - and - mol/dm were analyzed in vitro conditions in isolated specimens of tracheas of pigs, guinea pigs, and dead persons for diff erent reasons (), in the presence and without presence of propranolol. Whilst, research regarding actions of aerosolized histamines ( mg, , min), in the presence and without the presence of aerosolized propranolol ( mg, , min) was done in vivo in healthy persons. Study results show that propranolol does not emphasize contraction of the airways smooth musculature as induced by ACh, histamine, -HT and PGF-alfa in vitro conditions (p>,). Also, in vivo we found a non-signifi cance of tracheal smooth musculature constriction (p>,)