HYDROCHLORTHIAZIDE

Dose-related adverse eff ects of medications are a major problem in modern medical prac-tice. Th e “correct ” dose, based on drug company guidelines in package inserts, may not be correct for many patients. Tablet splitting or dividing has been an accepted practice for many years as a means of obtaining the prescribed dose of medication. As model tablets for this investigation, two batches of lisinopril- hydrochlorothiazide scored tablets labeled to contain /, mg were used. Th e aim of this study was to estab-lish possible infl uence of tablet splitting on content uniformity of lisinopril/hydrochlorthi-azide tablets. Determination of the content uniformity of lisinopril and hydrochlorthiazide in our batch-es, was carried out by HPLC method. Th e results of content uniformity studies for halves of tablets containing combination of lisinopril-hydrochlorthiazide (supposed to contain of stated /, mg in the whole tablet) were: , ±, and ,±, (lisinopril); ,±, and ,±, (hydrochlorthiazide) for batch I and II, respectively. We can conclude that the results obtained in this study support an option of tablet splitting, which is very important for obtaining the required dosage when a dosage form of the required strength is unavailable, and for better individualization of the therapy