Add to ORKGAbstract. Relevance of mode coupling to energy/information transfer during protein function, particularly in the context of allosteric interactions is widely accepted. However, existing evidence in favor of this hypothesis comes essentially from model systems. We here report a novel formal analysis of the near-native dynamics of myosin II, which allows us to explore the impact of the interaction between possibly non-Gaussian vibrational modes on fluctutational dynamics. We show that, an information-theoretic measure based on mode coupling alone yields a ranking of residues with a statistically significant bias favoring the functionally critical locations identified by experiments on myosin II. ar X i
Although the major structural transitions in molecular motors are often argued to couple to the bind...
Although the major structural transitions in molecular motors are often argued to couple to the bind...
Understanding how allosteric proteins respond to changes in their environment is a major goal of cur...
Relevance of mode coupling to energy/information transfer during protein function, particularly in t...
Relevance of mode coupling to energy/information transfer during protein function, particularly in t...
Relevance of mode coupling to energy/information transfer during protein function, particularly in t...
AbstractStructure-based elastic network models (ENMs) have been remarkably successful in describing ...
ABSTRACT It is now recognized that internal global protein dynamics play an important role in the al...
ABSTRACT It is now recognized that internal global protein dynamics play an important role in the al...
AbstractIt is now recognized that internal global protein dynamics play an important role in the all...
AbstractBased on the elastic network model, we develop a new analysis for protein complexes, which p...
AbstractIt is now recognized that internal global protein dynamics play an important role in the all...
The assumption of linear response of protein molecules to thermal noise or structural perturbations,...
The assumption of linear response of protein molecules to thermal noise or structural perturbations,...
Proteins retain specific structures and dynamics that are directly connected with their biological f...
Although the major structural transitions in molecular motors are often argued to couple to the bind...
Although the major structural transitions in molecular motors are often argued to couple to the bind...
Understanding how allosteric proteins respond to changes in their environment is a major goal of cur...
Relevance of mode coupling to energy/information transfer during protein function, particularly in t...
Relevance of mode coupling to energy/information transfer during protein function, particularly in t...
Relevance of mode coupling to energy/information transfer during protein function, particularly in t...
AbstractStructure-based elastic network models (ENMs) have been remarkably successful in describing ...
ABSTRACT It is now recognized that internal global protein dynamics play an important role in the al...
ABSTRACT It is now recognized that internal global protein dynamics play an important role in the al...
AbstractIt is now recognized that internal global protein dynamics play an important role in the all...
AbstractBased on the elastic network model, we develop a new analysis for protein complexes, which p...
AbstractIt is now recognized that internal global protein dynamics play an important role in the all...
The assumption of linear response of protein molecules to thermal noise or structural perturbations,...
The assumption of linear response of protein molecules to thermal noise or structural perturbations,...
Proteins retain specific structures and dynamics that are directly connected with their biological f...
Although the major structural transitions in molecular motors are often argued to couple to the bind...
Although the major structural transitions in molecular motors are often argued to couple to the bind...
Understanding how allosteric proteins respond to changes in their environment is a major goal of cur...