AS PREDICTORS OF

Gallbladder carcinoma is the fi fth most common malignancy of the gastrointestinal tract. O e absolute characteristics of the disease are the high mortality rate due to the late discovery of a tumor and the low therapeutic possibilities except by surgical intervention. In oncology we can predict the outcome of the disease with a com-bination of classical standard clinico/pathological parameters (stage of the tumors, diff erentiation) and the intrinsic genetic and biochemical properties of the tumor. Such intrinzic properties of the tumors that are connected with the outcome of the disease are the denominators (markers). O e author searched extensively for the expression and infl uence of markers included in chronic infl ammation and early carcinogenesis, cell cycle regulation and tissue hypoxia: cyclooxygenase- (COX-), p gene and glucose transporter- protein (GLUT-). O e author discusses their possible role in the development as well as fi ghting this disease, if specifi c medica-tions targeting them were available