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One of the major objectives of a root canal treatment is to disinfect the root canal system. Irrigation is carried out to reduce the number of bacteria in the root canals. For this purpose, a wide variety of synthetic drugs are available today but due to the ineffectiveness, safety concerns and side effects of these synthetic drugs, the herbal alternatives for endodontic irrigants might be advantageous.Over the past decade, interest in drugs derived from medicinal plants has markedly increased. In dentistry phytomedicine has been used as anti-inflammatory, antibiotic, analgesic, sedative and also as endodontic irrigant.This update focuses on various herbal drugs and products as well as their therapeutic application, side effects and possible drug interactions when used as phytomedicine in endodontics