OBJECTIVE REFERENCES

CONCLUSION Compare the results of Leuprolide stimulation test with ovarian volumes and uterine morphology assessed by pelvic sonography in females with suspected precocious puberty. Peak LH and estradiol values obtained with Leuprolide stimulation tests significantly correlate with ovarian and uterine volumes. Because of substantial variability, we recommend caution in the interpretation of data. Careful, long term clinical follow up is necessary to validate Leuprolide stimulation tests and sonographic findings. Average ovarian volume and Uterine volume were significantly larger in patients with pubertal response than in patients with prepubertal response (P=0.003 and P=0.03 respectively). Uterine lengths, however, were not significantly larger in patients with pubertal response than in patients with prepubertal response (P=0.48). Peak LH significantly correlated with average ovarian volume (r=0.40, P=0.009), uterine length (r=0.34, P=0.03) and uterine volume (r=0.50, P=0.0009). Peak Estradiol also significantly correlated with average ovarian volume (r=0.37, P=0.03) an