DRUG NAME: Lomustine

Special pediatric considerations are noted when applicable, otherwise adult provisions apply. MECHANISM OF ACTION: Lomustine is a highly lipid-soluble nitrosurea compound.4 Unlike carmustine, it is administered orally. Lomustine, a monofunctional alkylating agent, alkylates DNA and RNA, can cross-link DNA, and inhibits several enzymes by carbamoylation.5,6 It is cell cycle phase-nonspecific. Cross-resistance between carmustine and lomustine has occurred.1 PHARMACOKINETICS: Oral Absorption rapidly absorbed1 widely distributed1 cross blood brain barrier? passes readily;>50 % of concurrent plasma concentrations volume of distribution no information found Distribution plasma protein binding 50%7 hepatic8 active metabolite(s) yes1 Metabolism inactive metabolite(s) yes1 renal7; respiratory <10 % as CO2 urine metabolites feces <5%7 terminal half life 16-72 h7 active metabolite7: 31.2-48 h Excretion clearance no information found Adapted from standard reference2 unless specified otherwise. USES