SYNONYM(S): benzenepropanoic acid1 COMMON TRADE NAME(S): TAXOL®, ONXOL®

CLASSIFICATION: antimicrotubule agent Special pediatric considerations are noted when applicable, otherwise adult provisions apply. MECHANISM OF ACTION: Paclitaxel is a taxane. Paclitaxel binds to tubulin, the protein component of microtubules, simultaneously promoting their assembly and disassembly to form stable, nonfunctional microtubules.1,2 Although some reports indicate a cross-reactivity rate of 90 % between docetaxel and paclitaxel, others suggest it does not occur consistently.2,3 Stabilization of microtubules blocks cells in the M phase of the cell cycle, inhibiting cell division and causing cell death.2 Paclitaxel acts as a radiosensitizing agent by blocking cells in the G2phase.4 Paclitaxel is an immunosuppressant.5,6 PHARMACOKINETICS: Oral Absorption no information found Distribution biphasic: initial distribution to peripheral compartment, then slow efflux from the peripheral compartment; widely distributed into body fluids and tissues1,7; small changes in dose may lead to large changes in peak plasma concentrations and total drug exposure due to saturable, nonlinear pharmacokinetics